Overview

The Cb GRiTS Database resource represents a growing number of datasets for exploring cerebellar development of the mouse in time and space.

Microarray

The database contains a number of mutant/wildtype microarray datasets including two complete wildtype microarray time-series (C57BL/6 and DBA/2J). Our time-series data spans twelve time-points between E12-P9.  The dataset also includes in situ hybridization and bioinformatic analyses.

In Situ Hybridization

Exploration of this dataset will allow the investigator to assess differential gene expression profiles from a developing mutant cerebella, to assess the temporal changes in gene expression in the wildtype, and to verify the cellular expression of these genes in images from our in situ hybridization library.

Bioinformatic Analysis

Using our database, the investigator can explore the developmental expression or differential expression patterns of a particular gene, or create lists of similarly expression genes by building simple search algorithms. These lists can then be mined accross all the datasets in both space and time.

Current Datasets

Our current datasets represent gene expression analyses from multiple cerebellar mutant and wildtype single time-point and developmental series.

Future additions to the database will include a developmental series from BXD RI lines and an extensive survey of additional cerebellar mutant lines.