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Yan Cui, PhD
Associate Professor, UTHSC
Director of Bioinformatics Core
Phone: (901) 448-3240
Email: ycui2@utmem.edu
Additional Contact:
The University of Tennessee Health Science Center
Department of Molecular Sciences
101G Molecular Sciences Building
Memphis, TN 38163
Cui Lab Website
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Research:
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Elucidating causal pathways bridging genotype and phenotype is one of the fundamental
challenges for genetic and genomic research. Gene variants that control phenotypes
are typically discovered by combined linkage analysis and molecular validation.
However, these genotype-phenotype associations do not expose the underlying causal
pathways through which gene variants operate on phenotypes. We are exploring genomic
and computational approaches to uncover the causal pathways through which genetic
loci influence phenotypes and predict the effects of genetic and transcriptional
variations/interventions on gene expression and physiological/behavioral phenotypes
of individuals with different genetic backgrounds. We believe research towards this
direction will ultimately lead to the development of the computational methods that
enable personalized predictive genetics and medicine.
more...
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